an efficient one-pot synthesis of α-amino nitriles using ecofriendly lewis-acidic ionic liquid choline chloride.2zncl2
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abstract
α-amino nitriles are synthesized in a one-pot, three-component coupling of aldehydes (or ketones), aniline, and trimethylsilyl cyanide using a catalytic amount of choline chloride.2zncl2 as a bio lewis acidic ionic liquid. mild lewis acidic characteristic of this ionic liquid allows efficient synthesis of α-amino nitriles from acid sensitive aldehydes.
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Journal title:
iranian journal of catalysisPublisher: islamic azad university, shahreza branch
ISSN 2252-0236
volume 2
issue 4 2012
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